Rfam 9.1 : Telomerase-vert (Janelia)

Rfam 9.1 :: Telomerase-vert
Annotation and alignments for Rfam Telomerase-vert family

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Telomerase-vert (accession Vertebrate telomerase RNA):

Telomerase is a ribonucleoprotein reverse transcriptase that synthesises telomeric DNA. Telomerase RNAs differ greatly in sequence and structure between vertebrates, ciliates and yeasts, but they share a 5' pseudoknot structure close to the template sequence. Vertebrate telomerase RNAs have a 3' H/ACA snoRNA-like domain. This family also contains viral telomerase RNAs from the Gallid herpes viruses as described in [3].

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Literature References:

[1]
Secondary structure of vertebrate telomerase RNA.
Chen JL, Blasco MA, Greider CW;
Cell 2000;100:503-514.

[2]
Analysis of the structure of human telomerase RNA in vivo.
Antal M, Boros E, Solymosy F, Kiss T;
Nucleic Acids Res 2002;30:912-920.

[3]
Comparative functional study of the viral telomerase RNA based on natural mutations.
Fragnet L, Kut E, Rasschaert D;
J Biol Chem. 2005;280:23502-23515.

Rfam specific information:

Author of entry	Machado Lima A
Source of seed alignment	Machado Lima A
Gathering cutoff	50.00
Trusted cutoff	58.86
Noise cutoff	49.62
Build method of CM	cmbuild CM SEED; cmsearch --toponly CM SEQDB;